Custom Peptides
Cayman Chemical DesglymIdodrIn 10mg
An active metabolite of midodrine; an agonist of α1-ARs; binds to α1-ARs (Kis = 9.77, 9.55, and 8.51 µM for α1A, α1B, and α1D-ARs, respectively); increases IUP and MAP in anesthetized dogs by 5 and 20 mm Hg, respectively, in anesthetized dogs at 205 and 250 nmol/kg, respectively
Cayman Chemical CalIndolhydrochlorIde 10mg
A phenylalkylamine calcimimetic that facilitates the activation of CaSR, a GPCR that triggers PI-intracellular Ca2+ signaling; stimulates PI hydrolysis and proliferation through human CaSR (pEC50 values are 6.9 and 7.4, respectively) in the presence of calcium
Cayman Chemical 20 S-GInsenosIde Rh2 10mg
A natural steroid glycoside with diverse effects; inhibits release of β-hexosaminidase from RBL-2H3 cells (IC50 = 100 μM) and inhibits the IgE-dependent passive cutaneous anaphylaxis reaction in mice at a concentration of 25 mg/kg; inhibits growth of HRA ovarian and Bxpc-3 pancreatic cancer cells in a dose-dependent manner; decreases immobility time in the forced swim test in a mouse model of colorectal carcinoma; reduces infarct volume in a rat model of ischemia-reperfusion-induced brain injury
Cayman Chemical StearoylLcarnItInchLRId 10mg
A long-chain acylcarnitine; inhibits sodium-dependent [3H]carnitine uptake in HPCT cells by 52% at 500 μM; inhibits lecithin:cholesterol acyltransferase activity in rat, but not human, plasma at 500 μM/ml of plasma; levels are decreased in plasma of patients with chronic fatigue syndrome and increased in patients with end-stage renal disease
Cayman Chemical Cyclo -Ala-L-Val 5mg
A bacterial cyclic dipeptide; activates a LuxR-based AHL E. coli biosensor and blocks activation of the biosensor by the quorum sensing signal molecule 3-oxo-C6-HSL (IC50 = 0.8 mM); reduces S. liquefaciens colony expansion by 21% at 15 μM; inhibits interaction of kinases Ras and Raf-1 in a yeast two-hybrid assay in a concentration-dependent manner
Cayman Chemical NAADPsodIum salt 10mg
A secondary messenger that induces calcium mobilization; induces calcium release from endosomes and lysosomes via TPC2 and TPC1; induces calcium mobilization in sea urchin and starfish eggs post fertilization to block polyspermy and activate embryogenesis; induces VEGF-mediated angiogenesis in HUVECs; alkalizes lysosomal pH, arresting autophagic flux in mouse embryonic stem cells
Cayman Chemical AdomeglIvnt 10mg
An allosteric antagonist of the glucagon receptor; inhibits glucagon-induced increases in cAMP levels in HEK293 cells expressing the rat glucagon or GLP-1 receptors (IC50s = 1.8 and 1.2 µM, respectively) but has no effect on cAMP levels when used alone; inhibits increases in cAMP levels induced by GLP-1 or exendin-4 in HEK293 cells expressing the GLP-1 receptor (IC50s = 7 and 12 µM, respectively); decreases glucose-stimulated insulin secretion at 1 µM in combination with exendin (9-39) in isolated human islets but not glucose-stimulated glucagon secretion alone or in combination with exendin (9-39) in isolated mouse islets
Cayman Chemical CyclogunIlhydrochlorIde 10mg
The active metabolite of proguanil; formed from proguanil by CYP2C19 and CYP3A in human liver microsomes; an inhibitor of DHFR (Kis = 1.5 and 0.79 nM for the P. falciparum and P. berghei enzymes, respectively); active against ten P. falciparum field isolates (IC50s = 0.12-1,400 UG/ml); reduces parasitemia in a mouse model of P. berghei infection (ED50 = 2 mg/kg); reduces parasitemia in a rhesus monkey model of P. cynomolgi infection at 0.3 mg/kg
Cayman Chemical NundecnoylLHomoserIn lac 10mg
A bacterial quorum-sensing signaling molecule; induces GFP production in E. coli expressing the V. fischeri LuxR-PluxI quorum-sensing operon from 100-1,000 nM; inhibits concanavalin A-induced proliferation of isolated mouse splenocytes (IC50 = 90 µM)
Cayman Chemical 4ChLRomethamphetamInhydr 10mg
A halogenated analog of methamphetamine; converted to 4-chloroamphetamine in vivo
Cayman Chemical L-CarnItIn-d3chlorIde 10mg
An internal standard for the quantification of L-carnitine by GC- or LC-MS
Cayman Chemical ValerylLcarnItInchLRIde 10mg
A short-chain acylcarnitine; levels increase in the serum of rhesus monkeys following exposure to 7 and 10 Gy of ionizing radiation
Cayman Chemical AzumolensodIum salt 10mg
A muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum; inhibits a component of store-operated calcium entry (SOCE) that is coupled to the skeletal muscle ryanodine receptor, with 20 µM azumolene causing a 70% reduction in SOCE in myotubes