Custom Peptides
Cayman Chemical DSedoheptulose7phosphate 10mg
An intermediate in the pentose phosphate pathway, carbon fixation in photosynthetic organisms, and the biosynthesis of lipopolysaccharide, amino acids, secondary metabolites, and antibiotics
Cayman Chemical SB-258585hydrochlorIde 10mg
A potent, selective antagonist of the serotonin 5-HT6 receptor (pKi = 8.53); has been used in cells and in animals
Cayman Chemical Talabostatmesylate 10mg
A non-selective inhibitor of DPPs (IC50s = >4, 310, 4, 11, 560, and 390 nM for DPP-4, DPP-7, DPP-8, DPP-9, FAP, and PREP, respectively); inhibits proliferation of superantigen-stimulated human PBMCs (IC50 = ~10 nM); increases expression of a variety of cytokines and chemokines in tumors and tumor-draining lymph nodes in a WEHI-164 fibrosarcoma mouse model at 5 μg twice per day; reduces tumor growth in a variety of syngeneic mouse models; increases the efficacy of the antitumor antibodies rituximab and trastuzumab in Namalwa B cell lymphoma and LS180 colon carcinoma mouse xenograft models, respectively
Cayman Chemical OlutasIdenIb 10mg
An inhibitor of mutant IDH1 (IC50s = 0.021 and 0.114 µM for IDH1R132H and IDH1R132C, respectively); selective for mutant IDH1 over wild-type IDH1 and mutant IDH2 (IC50s = 22.4, 27.3, and >100 μM for wild-type IDH1, IDH2R172K, and IDH2R140Q, respectively); inhibits production of 2-HG in U87 cells expressing mutant IDH1R132H, IDH1R132C, IDH1R132L, IDH1R132G, and IDH1R132S (IC50s = 0.009, 0.039, 0.042, 0.006, and 0.009 µM, respectively); reduces intratumor 2-HG levels in HCT116-IDH1R132H and HCT116-IDH1R132C mouse xenograft models at 12.5, 25, and 50 mg/kg
Cayman Chemical CeramIdenon-hydroxybovIn 10mg
A mixture of non-hydroxy fatty acid-containing ceramides
Cayman Chemical nC-711hydrochlorIde 10mg
A GAT-1 inhibitor (IC50 = 0.04 µM for the human transporter); selective for GAT-1 over human GAT-3 and BGT-3 (IC50s = 1,700 and 622 µM, respectively), rat GAT-2 (IC50 = 171 µM), and a panel of 21 receptors and ion channels (IC50s = >50 µM for all) in radioligand binding assays; inhibits GABA uptake in rat synaptosome preparations, neurons, and glia (IC50s = 47, 1,238, and 636 nM, respectively); inhibits PTZ- or DMCM-induced clonic seizures in mice (ED50s = 1.2 and 3 mg/kg, respectively), as well as audiogenic tonic seizures in mice (ED50 = 0.23 mg/kg) and PTZ-induced tonic seizures in rats (ED50 = 1.7 mg/kg); intrathecal administration decreases mechanical allodynia and thermal hyperalgesia in a rat model of CCI-induced neuropathic pain at 100 or 200 UG/animal
Cayman Chemical PhosphatIdylserInsoysod 10mg
A mixture of soy phosphatidylserines; comprises 2-10% of total phospholipids in mammals and is enriched in the brain; found mainly on the inner leaflet of the cell membrane; synthesized in the ER and mitochondria; is a precursor to phosphatidylcholine and phosphatidylethanolamine; cofactor for various signaling pathways; externalized during apoptosis as a signal for phagocytes to engulf the cell
Cayman Chemical CyclopentolatehydroCLOrID 10mg
A muscarinic receptor antagonist (Kis = 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively); inhibits carbachol-induced contraction of isolated human iris sphincter, circular ciliary muscle, and longitudinal ciliary muscle (Kbs = 7.9, 15.8, and 12.5 nM, respectively)
Cayman Chemical LY334370hydrochlorIde 10mg
A 5-HT1F receptor agonist (Kd =0.446 nM); selective for 5-HT1F over other G protein-coupled 5-HT receptor subtypes (Kis = 16.4->3,000 nM); inhibits forskolin-induced cAMP accumulation in mouse L-M(TK-) cell membranes expressing the recombinant human 5-HT1F receptor (EC50 = 1.51 nM); decreases electrically stimulated extravasation of plasma proteins in the dura mater in a guinea pig trigeminal nerve model of migraine headache.
Cayman Chemical JWH 018 N 2hydroxypenty 10mg
A potential metabolite of JWH 018, detectable in serum and in urine
Cayman Chemical SynthetIc ArtemItIn 10mg
A flavonoid with diverse biological activities; scavenges peroxyl radicals in a cell-free assay; inhibits 5-LO (IC50 = 54.6 µM); active against P. falciparum (IC50 = 26 µM); cytotoxic to HL-60 leukemia cells (IC50 = 30.98 µM); decreases mean arterial blood pressure in normotensive rats, as well as reduces angiotensin I-induced, but not angiotensin II-induced, increases in mean arterial blood pressure in rats, at 0.75 mg/kg
Cayman Chemical CIlengItIDtrIfluoROCTAte 10mg
An integrin αVβ3 receptor antagonist; inhibits adhesion and induces apoptosis of U87MG and U373MG, but not U251MG cells that lack the integrin αVβ3 receptor, in vitro at a concentration of 20 μg/ml; delays tumor implantation time, reduces tumor growth, and prolongs survival in a U87MG mouse model of glioblastoma when administered at a dose of 200 μg/animal per day
Cayman Chemical IRBP1-20humnratrI 10mg
A peptide inducer of experimental autoimmune uveoretinitis; increases the levels of IL-4, IL-5, and IL-6 secreted from primary mouse spleen lymphocytes at 3 µM; immunization and rechallenge increases EAr swelling in IFN-γ-deficient mice; induces ocular blood vessel inflammation, immune cell infiltration, and photoreceptor layer damage, as well as retinal detachment, in the same mice
Cayman Chemical ML-7hydrochlorIde 10mg
Inhibits smooth MLCK (Ki = 0.3 µM) 10-fold more potently than its parent compound ML-9