Custom Peptides
Cayman Chemical 17phenyl trInor PrstglndI 10mg
An inhibitor of Akt1 and Akt2 with anticancer activity inhibits Akt1 and Akt2 in a kinase assay but has no effect on MEK1 JNK1 ERK1 or PBK at 1 UM increases apoptosis in HCT116 and HT-29 colon cancer cells at 4 UM inhibits growth of HCT116 cells in vitro reduces tumor growth in an HCT116 mouse xenograft model at 30 mg/kg decreases status epilepticus-induced vasogenic edema and reduces increases in eNOS levels in the piriform cortex in rats at 25 UM
Cayman Chemical SotalolhydrochlorIde 10mg
A pan-HDAC inhibitor (Kis 0.6-31 nM for HDAC1-11) inhibits growth in a panel of 37 human or mouse lung cancer cell lines including SCLC NSCLC and mesothelioma cells (IC50s 4-175 5-310 and 5-470 nM respectively) induces tumor regression in BK-T and RG-1 SCLC mouse xenograft models at 20 mg/kg i.p.
Cayman Chemical FSlRY-amIde 10mg
A pentacyclic triperpene isolated from birch tree bark that inhibits the SREBP-driven pathway of cholesterol and fatty acid biosynthesis 15-30 mg/kg/day decreases lipid levels and increases insulin sensitivity in mice fed a western-type diet and reduces the size and improves the stability of atherosclerotic plaques in LDLR-knockout mice
Cayman Chemical Xnthohumol 10mg
A metabolite of JWH 122 that is characterized by monohydroxylation of the N-alkyl chain
Cayman Chemical ClorgylInhydrochlorIde 10mg
A major urinary metabolite of PGD2 with a unique lower sidechain that readily undergoes reversible cyclization used as a biomarker to assess endogenous production of PGD2
Cayman Chemical -TalInolol 10mg
A potential designer drug created by inserting a methylene group in the methylamphetamine portion of MDMA
Cayman Chemical BazedoxIfenacetate 10mg
A macrolactam that binds to macrophilin-12 and inhibits calcineurin as well as prolyl isomerase the activation of T cells by allogeneic dendritic cells (IC50 0.55 nM) and suppresses the generation of pro-inflammatory cytokines used in countering inflammatory skin diseases such as eczema and psoriasis
Cayman Chemical 4ChLRomethcathInonhydroc 10mg
A potent HIV-1 protease inhibitor (Ki 1.3 pM for wild-type enzyme) inhibits the replication of clinical isolates of HIV-1 (EC50s 5-52 nM) reduces the infectious virus yield and viral RNA copy numbers in the culture supernatant of Vero E6 cells infected with SARS-CoV-2 (EC50s 26.63 and 26.10 UM respectively) reduces lung and kidney viral load bronchointerstitial pneumonia and pulmonary inflammatory cell infiltration in a marmoset model of MERS-CoV when administered in combination with ritonavir
Cayman Chemical GInsenosIde Re 10mg
An inhibitor of Bcl-2 family proteins (Kis is 550 and 354 nM respectively) cytotoxic in a panel of SCLC leukemia and lymphoma cell lines (mean EC50 1 UM) induces apoptosis in influenza A-infected retinal pigment epithelial cells (EC50 0.08 UM) induces tumor regression in NCI H146 SCLC and RS411 ALL mouse xenograft models at 100 mg/kg
Cayman Chemical aHydroxyglutarIc AcIdodIu 10mg
A stable monomethoxylated resveratrol derivative that at 0.1-10 M reduces neurotoxicity in SH-SY5Y cells induced by the parkinsonian mimetic 6-OHDA and scavenges DPPH radicals (IC50 47.1 M)
Cayman Chemical 5-fluoro THJ 10mg
An MDMA analog that appears to act as a serotonin-norepinephrine-dopamine releasing agent binding to and inhibiting uptake at noradrenalin and serotonin transporters (Kis 22.8 and 7.7 M and IC50s 253.4 and 108 M respectively) significantly less potent than MDMA intended for forensic and research applications
Cayman Chemical PROSGlnDN F2a 1 11lacton 10mg
A natural 14-naphthoquinone that has diverse effects in cells and animals causes the generation of ROS and induces apoptosis in cancer cells activates signaling through Nrf2 and ARE inducing the expression of Nrf2 target genes including NQO1 and HO-1 in cultured neuronal cells
Cayman Chemical DSmethyldoxepInhydroCLOrI 10mg
A racemic mixture of (25R)-4-dafachronic acid and (25S)-4-dafachronic acid an agonist of DAF-12 a metabolite of cholesterol in C. elegans induces transactivation of DAF-12 in NIH3T3 cells expressing the C. elegans or D. immitis receptor (EC50s 81 and 0.65 nM respectively) induces molting of infective D. immitis (heartworm) third-stage larvae into L4 larvae induces the escape trajectory in embryos of the annual killifish A. limnaeus at 25°C at 75 UM
Cayman Chemical 3methoxy ProstaglndIn F1a 10mg
A PDE5 inhibitor (IC50s 3.6 and 3 nM for PDE5 activity in isolated rabbit platelets and human corpus cavernosum respectively) selective for PDE5 over PDE1 and PDE3 (IC50s 0.26 and 65 M respectively) reverses glucose-induced decreases in ANG1 expression and reduction of capillary-like tube formation by mouse dermal endothelial cells in vitro increases the number of functional blood vessels and regional blood flow in the sciatic nerve in a db/db mouse model of diabetic peripheral neuropathy increases ICP/MAP ratio in castrated rats at 20 mg/kg per day reduces cardiac arrest and resuscitation-induced increases in angiotensin II ACE ACE2 and various angiotensin receptors and increases survival in a porcine model of ischemia/reperfusion injury